Radioboss, Sound Blaster sound card and Mixer

Hello,
I have had to switch machines, and want to try something new. The machine I am using has a very nice sound blaster sound card in it. Whenever I've used Radioboss with a mixer before, the Mixer was set to use USB for both input and output. So, if I set output from Radioboss to the sound card, thus going to a specific channel on the board, but input is set to the board for input 1, will this creat any undesired consequences, such as echos, feedback, etc? Or, am I good to go with this setup? Anything else you would recommend me changing?
 
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